Charles F. Baer

High rate of mutation and efficient removal by selection of structural variants from natural populations of Caenorhabditis elegans

The paper estimates the mutation rate and removal efficiency of structural variants in C. elegans using long-read sequencing and finds a lower mutation rate compared to SNVs and short indels, with natural selection effectively removing SVs in both exonic and intergenic regions.

Evolution of the rate, spectrum, and fitness effects of mutation under minimal selection in Caenorhabditis elegans

This study tracks mutation rates and fitness effects in C. elegans under minimal selection, finding increased indel mutation rates and no change in nucleotide substitution rates.

Direct inference of the distribution of fitness effects of spontaneous mutations from recombinant inbred C. elegans mutation accumulation lines

This study infers the distribution of fitness effects of mutations in C. elegans using recombinant inbred lines, finding that positive effects are common but LD can skew results.

Pervasive conservation of intron number and other genetic elements revealed by a chromosome-level genomic assembly of the hyper-polymorphic nematode Caenorhabditis brenneri

This study presents a chromosome-level genome assembly of C. brenneri, revealing conserved intron number patterns and genome organization despite high genetic diversity.

Mutation, selection, and the prevalence of the C. elegans mortal germline phenotype

The paper quantifies mutation rates and selection pressures for the Mrt phenotype in C. elegans, suggesting balancing selection maintains weak Mrt variants.

Network Architecture and Mutational Sensitivity of the C. elegans Metabolome

The paper investigates the relationship between topological properties of the C. elegans metabolic network and mutational sensitivity of metabolites, finding weak correlations and some significant negative associations.