A Glycosylation-Dependent Checkpoint Restrains Intestinal Intra-Epithelial Lymphocyte Activation
Liqing Cheng, Niccolò Bianchi, Hadrien Soldati, Ludivine Bersier, Maximilien Evrard, Aurélie Caillon, Amanpreet Singh Chawla, Britt Nakken, Péter Szodoray, Elien De Bousser, Nele Festjens, Tatiana V. Petrova, Sylvain Lemeille, Laura K. Mackay, Nico Callewaert, , Simone Becattini
This study identifies GCNT2 as a glycosylation-dependent checkpoint that restrains intestinal intra-epithelial lymphocyte (IEL) activation by modifying CD45 and dampening TCR signaling.
bioRxiv · Jun 16, 2026 · PreprintImmunology