Amanpreet Singh Chawla

This study identifies GCNT2 as a glycosylation-dependent checkpoint that restrains intestinal intra-epithelial lymphocyte (IEL) activation by modifying CD45 and dampening TCR signaling.

This study shows that intraepithelial lymphocytes (IELs) are critical for resisting specific intestinal pathogens but not for maintaining intestinal homeostasis or other infections.

The paper investigates the role of LRRK2 in lysozyme expression in Paneth cells and finds that LRRK2 is not required for lysozyme expression in the murine gut and is not expressed in Paneth cells.