Micropatterned Organoids Enable Modeling of the Earliest Stages of Human Cardiac Vascularization
Oscar John Abilez, Huaxiao Yang, Yuan Guan, Mengcheng Shen, Zehra Yıldırım, Yan Zhuge, Ravichandra Venkateshappa, Shane Rui Zhao, Angello Huerta Gomez, Marcel El‐Mokahal, Logan Dunkenberger, Yoshikazu Ono, Masafumi Shibata, Peter N. Nwokoye, Lei Tian, , Joseph C. Wu
The paper demonstrates that micropatterned human pluripotent stem cells can model early human cardiac vascularization in vitro, resembling a 6.5 post-conception week heart and revealing conserved vascular development programs.
Science · Jun 5, 2025Peer-reviewedDevelopmental Biology