Author

Detlef Obal

Stanford MedicineORCID 0000-0002-1126-2132Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 1 Pharmacology & Toxicology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell-cell communication· 1 Research Focus:gene regulatory network inference· 1 Assay:metabolomics· 1

Frequent Co-Authors

Angello Huerta Gomez· 1 shared Aruni BhatnagariD· 1 shared Ben Doeling· 1 shared Bryan AldanaiD· 1 shared Christopher Kristaps ZarinsiD· 1 shared Claudius BalzeriD· 1 shared David Hoetker· 1 shared Demetris YannopoulosiD· 1 shared

Activity by Year

2021-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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1 shared paperDevelopmental Biology

Angello Huerta Gomez

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3 papers

Recent·Most cited

Micropatterned Organoids Enable Modeling of the Earliest Stages of Human Cardiac Vascularization

Oscar John Abilez, Huaxiao Yang, Yuan Guan, Mengcheng Shen, Zehra Yıldırım, Yan Zhuge, Ravichandra Venkateshappa, Shane Rui Zhao, Angello Huerta Gomez, Marcel El‐Mokahal, Logan Dunkenberger, Yoshikazu Ono, Masafumi Shibata, Peter N. Nwokoye, Lei Tian, , Joseph C. Wu

The paper demonstrates that micropatterned human pluripotent stem cells can model early human cardiac vascularization in vitro, resembling a 6.5 post-conception week heart and revealing conserved vascular development programs.

Science · Jun 5, 2025Peer-reviewedDevelopmental Biology

Cardioprotection by Poloxamer 188 is Mediated through Increased Endothelial Nitric Oxide Production

Gaoxian Chen, Hunter F. Douglas, Zhu Li, William J. Cleveland, Claudius Balzer, Demetris Yannopoulos, I. Y.-L. Chen, Detlef Obal, Matthias L. Riess

This study shows that Poloxamer 188 protects against ischemia/reperfusion injury by increasing endothelial nitric oxide production in both cell and rat models.

Scientific Reports · Apr 30, 2025Peer-reviewedPharmacology & Toxicology

Multiomics reveals the genomic, proteomic and metabolic influences of histidyl dipeptides on heart

Keqing Yan, Zhanlong Mei, Jingjing Zhao, Md Aminul Islam Prodhan, Detlef Obal, Kartik Katragadda, Ben Doeling, David Hoetker, Dheeraj Kumar Posa, Liqing He, Xinmin Yin, Jasmit Shah, Jianmin Pan, Shesh Nath Rai, Pawel Konrad Lorkiewicz, , Shahid P. Baba

This study uses multiomics to show histidyl dipeptides regulate heart function by altering microRNAs, proteins, and metabolites involved in fatty acid oxidation and the TCA cycle.

bioRxiv · Aug 10, 2021 · PreprintSystems Biology