Extrachromosomal DNA Gives Cancer a New Evolutionary Pathway
Yue Wang, Oliver Cope, Jingting Chen, Aarav Mehta, Dalia Fleifel, Christina Ford, Poorya Behnamie, Molly Murray, Santiago Haase, Saygin Gulec, Logan Slade, Tim C. Elston, Philip M. Spanheimer, Caroline A Tomblin, Alison M. Rojas, , Elizabeth Brunk
The paper shows that ecDNA allows tumors to adapt rapidly by maintaining a spectrum of gene expression levels across cells, rather than relying on clonal expansion.
bioRxiv · Apr 26, 2025 · PreprintGenomics