Polyamines buffer labile iron to suppress ferroptosis
Pushkal Sharma, Heather R. Keys, Ryan P. Mansell, Jillian Stark, Louisa Girard, Christalyn Ausler, Rachel Anderson, Sebastian Müller, Shinya Imada, Ivan Susin Pires, Tenzin Kunchok, Millenia Waite, Bingbing Yuan, Amy Deik, Luke S. Ferro, , Ankur Jain
This study shows polyamines buffer labile iron to suppress ferroptosis by linking polyamine metabolism to iron homeostasis through a genome-wide CRISPR screen and fluorescent reporter.
Cell · Aug 14, 2026Peer-reviewedCell Biology