Sebastian Müller

Polyamines buffer labile iron to suppress ferroptosis

This study shows polyamines buffer labile iron to suppress ferroptosis by linking polyamine metabolism to iron homeostasis through a genome-wide CRISPR screen and fluorescent reporter.

Ether lipids influence cancer cell fate by modulating iron uptake

This study shows that ether lipids in cancer cells regulate membrane properties to influence iron uptake, ferroptosis, and metastasis, offering a therapeutic target.

Sodium Aurothiomalate Induces Ferroptosis by Targeting GPX4 via Gold-Dependent Thiomalate Covalent Modification

This study shows sodium aurothiomalate induces ferroptosis by covalently modifying GPX4 through a gold-dependent mechanism, leading to tumor growth reduction in preclinical models.