Author

Luciano H. Di Stefano

University Medical Center Groningen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Molecular Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:protein design· 2 Research Focus:protein structure prediction· 2 Assay:proteomics· 2 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Research Focus:perturbation response prediction· 1

Frequent Co-Authors

John LaCavaiD· 2 shared Mehrnoosh OghbaieiD· 2 shared Alienke van PijkereniD· 1 shared Apostolos MourtzinosiD· 1 shared Brian T. ChaitiD· 1 shared David Coit· 1 shared Emma GerritsiD· 1 shared Gabriel Vasata FurtadoiD· 1 shared

Activity by Year

2022-2025 · peak 1/yr

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10 top collaborators · 30 mutual co-author links

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2 shared papersMolecular Biology

John LaCavaORCID

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2 papers

Recent·Most cited

Molecular BiologyMobile DNAPeer-reviewedFeb 6, 2025

Targeted detection of endogenous LINE-1 proteins and ORF2p interactions

Mathias Ingemann Nielsen, Justina Clarinda Wolters, Omar G. Rosas Bringas…·John LaCava

This paper develops targeted mass spectrometry assays to detect and quantify endogenous ORF1p and ORF2p proteins, demonstrating sensitive and robust quantitation of ORF2p for the first time.

10 citations

proteomicsexperimental assay

𝕏 PostBluesky

Molecular BiologyeLifePeer-reviewedJan 11, 2022

Targeting DNA topoisomerases or checkpoint kinases results in an overload of chaperone systems, triggering aggregation of a metastable subproteome

Wouter Huiting, Suzanne L. Dekker, Joris CJ van der Lienden…·Steven Bergink

The paper shows that targeting ATM, ATR, or DNA topoisomerases causes widespread protein aggregation through chaperone system overload, similar to proteotoxic stress and proteinopathies.

19 citations

humanproteomics

𝕏 PostBluesky