John LaCava

This study shows reverse transcriptase inhibitors induce autophagy in cancer cells through LINE-1 ORF1p-dependent mechanisms involving DNA damage and lamin B1 interactions.

This study identifies selenoprotein S's role in connecting translation with ER membrane protein biogenesis and quality control through its C-terminal redox loop.

This study investigates how O-mannose glycosylations on E-cadherin affect its protein interactions, showing O-Man-dependent changes in CDH1 associations with CDH3 and other proteins.

The paper uses Nanopore long-read DNA sequencing to analyze retrotransposon activation in aged and Alzheimer's disease brains, identifying somatic insertions and epigenetic changes.

The paper quantifies viral mimicry in genomes across species and shows how repetitive elements maintain pathogen-like features under selection.

This paper develops targeted mass spectrometry assays to detect and quantify endogenous ORF1p and ORF2p proteins, demonstrating sensitive and robust quantitation of ORF2p for the first time.

The paper shows that targeting ATM, ATR, or DNA topoisomerases causes widespread protein aggregation through chaperone system overload, similar to proteotoxic stress and proteinopathies.

This study identifies NCBP3 as a component of an alternative CBC complex that interacts with EJC and TREX, supporting mRNA processing and nuclear export.

Complex+ integrates and curates protein interaction data to help researchers identify reliable interactors and guide future experiments.

The paper identifies distinct nuclear and cytoplasmic intermediates of LINE-1 retrotransposition using mass spectrometry and affinity purification.