Enantioselective Protein Affinity Selection Mass Spectrometry (E-ASMS)
Xiaoyun Wang, Jianxian Sun, Shabbir Ahmad, Diwen Yang, Fengling Li, U Hang Chan, Hong Zeng, Conrad Veranso Simoben, Stuart R. Green, Madhushika Silva, Scott Houliston, Aiping Dong, Albina Bolotokova, Elisa Gibson, Maria Kutera, , Levon Halabelian
This study introduces E-ASMS, a method to detect weak binders and assess enantioselectivity, identifying 16 binders across 12 human protein targets with confirmed binding mechanisms.
Nature Communications · Dec 17, 2025Peer-reviewedPharmacology & Toxicology