Tyler S. Beyett

This paper develops covalent EGFR inhibitors targeting cysteine 775 and 797, showing improved efficacy and resistance delay in osimertinib-resistant models.

This study reports the crystal structure of the THEMIS CABIT1 domain and shows that LCK phosphorylation enables its interaction with SHP1 and protects SHP1 from ROS inhibition.

The paper uses high-throughput affinity-selection mass spectrometry to identify protein targets of ToxCast and PFAS compounds, discovering novel interactions and revealing distinct binding patterns of legacy and replacement PFAS.

This study introduces E-ASMS, a method to detect weak binders and assess enantioselectivity, identifying 16 binders across 12 human protein targets with confirmed binding mechanisms.

This study develops and evaluates [18F]P4B-2412 as a PET radioligand for imaging PDE4B, showing high binding, specificity, and metabolic stability in rodent models.

The paper reports the crystal structure of the THEMIS CABIT2 domain, revealing a novel fold with an inserted SH3-like domain and insights into its interaction with GRB2.