Author

Lukas Gleue

Johannes Gutenberg University Mainz

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Molecular Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1

Frequent Co-Authors

Annabelle Carolin WeldertiD· 1 shared Ariane F. FreyiD· 1 shared Collin ZimmeriD· 1 shared Fabian BarthelsiD· 1 shared Irmgard SinningiD· 1 shared Jürgen Kopp· 1 shared Kristina FriedlandiD· 1 shared Mark HelmiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperMolecular Biology

Annabelle Carolin WeldertORCID

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1 paper

Recent·Most cited

DNA-encoded Library Screening Uncovers Potent DNMT2 Inhibitors Targeting a Cryptic Allosteric Binding Site

Ariane F. Frey, Merlin Schwan, Annabelle Carolin Weldert, Valerie Kadenbach, Jürgen Kopp, Zarina Nidoieva, Robert A. Zimmermann, Lukas Gleue, Collin Zimmer, Marko Jörg, Kristina Friedland, Mark Helm, Irmgard Sinning, Fabian Barthels

This study identifies potent DNMT2 inhibitors through DNA-encoded library screening, revealing a cryptic allosteric binding site and optimizing an inhibitor with low nanomolar affinity.

iScience · Aug 6, 2025Peer-reviewedMolecular Biology