Author

Jürgen Kopp

Heidelberg UniversityPrimary ORCID profile (0000-0001-5633-7399 · 1 paper)Unclaimed ORCID profile · follow to get notified of new preprints

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Same name, identified by ORCID

Jürgen KoppiD1 paper · Heidelberg University

Biology Disciplines

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Biochemistry· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Approach:biophysical modeling· 1 Organism:human· 1 Organism:non-human primate· 1

Frequent Co-Authors

Irmgard SinningiD· 2 shared Merlin SchwaniD· 2 shared Annabelle Carolin WeldertiD· 1 shared Ariane F. FreyiD· 1 shared Axel MogkiD· 1 shared Bernd BukauiD· 1 shared Britta Jehle· 1 shared Collin ZimmeriD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersBiochemistry

Irmgard SinningORCID

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2 papers

Recent·Most cited

Small-molecule activators of the Staphylococcus aureus ClpC/ClpP AAA+ protease

Timo Jenne, Vsevolod Viliuga, Ulrike Uhrig, Britta Jehle, Merlin Schwan, Jürgen Kopp, Dirk Flemming, Elisabeth Seebach, Irmgard Sinning, Bernd Bukau, Axel Mogk

The paper identifies small-molecule activators of the Staphylococcus aureus ClpC/ClpP protease through high-throughput screening and characterizes their binding sites.

iScience · Sep 22, 2026Peer-reviewedBiochemistry

DNA-encoded Library Screening Uncovers Potent DNMT2 Inhibitors Targeting a Cryptic Allosteric Binding Site

Ariane F. Frey, Merlin Schwan, Annabelle Carolin Weldert, Valerie Kadenbach, Jürgen Kopp, Zarina Nidoieva, Robert A. Zimmermann, Lukas Gleue, Collin Zimmer, Marko Jörg, Kristina Friedland, Mark Helm, Irmgard Sinning, Fabian Barthels

This study identifies potent DNMT2 inhibitors through DNA-encoded library screening, revealing a cryptic allosteric binding site and optimizing an inhibitor with low nanomolar affinity.

iScience · Aug 6, 2025Peer-reviewedMolecular Biology