Author

Lukas Lütje

Max Planck Institute for Psycholinguistics

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 3 Genetic & Genomic Medicine· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 4 Research Focus:differential expression· 3 Organism:human· 3 Assay:spatial transcriptomics· 3 Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Organism:mouse· 2

Frequent Co-Authors

Simon E. FisheriD· 4 shared Clyde FrancksiD· 2 shared Maggie M. K. WongiD· 2 shared Alexander J.M. DingemansiD· 1 shared Alexander P.A. StegmanniD· 1 shared Amaia Lasa‐AranzastiiD· 1 shared Andrew SilberfeldiD· 1 shared Anne‐Sophie Denommé‐PichoniD· 1 shared

Activity by Year

2022-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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4 shared papersNeuroscience

Simon E. FisherORCID

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Author profile →

5 papers

Recent·Most cited

Perfect imperfections: seeking molecular and cellular asymmetries in the mouse brain

Danielle J. Houwing, Mengyun Wang, Andrew Silberfeld, Josephus A. van Hulten, Lukas Lütje, Judith Regina Homberg, Simon E. Fisher, Joanes Grandjean, Clyde Francks

The paper uses spatial transcriptomics to analyze left-right gene expression and cell type differences in mouse brain regions, finding transcriptional asymmetries but no significant cell type abundance differences.

bioRxiv · Sep 11, 2025 · PreprintNeuroscience

The neocortical infrastructure for language involves region-specific patterns of laminar gene expression

Maggie M.K. Wong, Zhiqiang Sha, Lukas Lütje, Xiangzhen Kong, Niels Velthuijs, Wilma D. J. van de Berg, Laura E. Jonkman, Simon E. Fisher, Clyde Francks

The paper identifies region-specific laminar gene expression patterns in language-related cortical areas and links them to structural connectivity and dyslexia risk.

Proceedings of the National Academy of Sciences · Aug 12, 2024Peer-reviewedGenetics

The chromatin remodeler CHD3 is highly expressed in mature neurons and regulates genes involved in synaptic development and function

Joery den Hoed, Maggie M. K. Wong, Willemijn J. J. Claassen, Lucía de Hoyos, Lukas Lütje, Michael Heide, Wieland Β. Huttner, Simon E. Fisher

This study investigates the role of CHD3 in human brain development using genetically modified organoids, finding it regulates synaptic development genes without affecting early neurogenesis.

bioRxiv · Apr 29, 2024 · PreprintNeuroscience

FriendlyClearMap: An optimized toolkit for mouse brain mapping and analysis

Moritz Negwer, Bram Bosch, Maren Bormann, Rick Hesen, Lukas Lütje, Lynn Aarts, Carleen Rossing, Nael Nadif Kasri, Dirk Schubert

FriendlyClearMap simplifies and extends the ClearMap pipeline for mouse brain analysis, enabling efficient and scalable neuroanatomical studies.

GigaScience · Dec 28, 2022Peer-reviewedNeuroscience

Missense variants in ANKRD11 cause KBG syndrome by impairment of stability or transcriptional activity of the encoded protein

Elke de Boer, Charlotte W. Ockeloen, Rosalie A. Kampen, Juliet E. Hampstead, Alexander J.M. Dingemans, Dmitrijs Rots, Lukas Lütje, Tazeen Ashraf, Rachel Baker, Mouna Barat‐Houari, Brad Angle, Nicolas Chatron, the DDD study, Anne‐Sophie Denommé‐Pichon, Orrin Devinsky, , Tjitske Kleefstra

This study identifies ANKRD11 missense variants as a cause of KBG syndrome by impairing protein stability or transcriptional activity, supporting haploinsufficiency as the underlying mechanism.

Genetics in Medicine · Jul 14, 2022Peer-reviewedGenetic & Genomic Medicine