Tri-AD: Hippocampal cell-type-specific responses to age, sex and APOE genotype
Yaqiao Li, Yanxia Hao, Carlota Pereda Serras, Luokang Yao, Zherui Liang, Ana Almonte-Loya, Jessica R. Blumenfeld, Kaylie Suan, Seo Yeon Yoon, Brian P. Grone, Leonardo Ding, Yichuan Ma, Shiyao Sun, Boris Oskotsky, Tomiko Oskotsky, , Marina Sirota
The paper investigates how age, sex, and APOE genotype affect hippocampal cell-type-specific gene expression and communication in mice, revealing sex-divergent effects of APOE4.
bioRxiv · Dec 8, 2025 · PreprintBioinformatics