Author

Leonardo Ding

Gladstone InstitutesORCID 0009-0005-7691-5244Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:mouse· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Assay:snRNA-seq· 1

Frequent Co-Authors

Brian P. GroneiD· 2 shared Jessica R. BlumenfeldiD· 2 shared Seo Yeon YooniD· 2 shared Yadong HuangiD· 2 shared Yanxia Hao· 2 shared Yaqiao LiiD· 2 shared Zherui LiangiD· 2 shared Alex R. Zhang· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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2 shared papersNeuroscience

Brian P. GroneORCID

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2 papers

Recent·Most cited

NeuroscienceNature AgingPeer-reviewedApr 3, 2026

Neuronal APOE4-induced Early Hippocampal Network Hyperexcitability in Alzheimers Disease Pathogenesis

Dennis R. Tabuena, Sung-Soo Jang, Brian P. Grone…·Misha Y. Zilberter

This study identifies early hippocampal network hyperexcitability in APOE4 mice, linked to Nell2 overexpression, and shows its role in AD pathogenesis.

10 citationstop 1%

mousebulk RNA-seq

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BioinformaticsbioRxivPreprintDec 8, 2025

Tri-AD: Hippocampal cell-type-specific responses to age, sex and APOE genotype

Yaqiao Li, Yanxia Hao, Carlota Pereda Serras…·Marina Sirota

The paper investigates how age, sex, and APOE genotype affect hippocampal cell-type-specific gene expression and communication in mice, revealing sex-divergent effects of APOE4.

DOI 10.64898/2025.12.03.691944

mousesnRNA-seq

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