Author

Zherui Liang

Gladstone InstitutesORCID 0009-0001-7312-3410Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Research Focus:differential expression· 4 Organism:mouse· 4 Approach:statistical model· 4 Assay:bulk RNA-seq· 3 Approach:experimental assay· 3 Research Focus:cell-cell communication· 2 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Jessica R. BlumenfeldiD· 4 shared Yadong HuangiD· 4 shared Yanxia Hao· 4 shared Brian P. GroneiD· 3 shared Nicole KoutsodendrisiD· 3 shared Oscar YipiD· 3 shared Seo Yeon YooniD· 3 shared Antara T. RaoiD· 2 shared

Activity by Year

2023-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

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4 shared papersNeuroscience

Jessica R. BlumenfeldORCID

Mutual co-authors in cluster

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4 papers

Recent·Most cited

NeuroscienceNature AgingPeer-reviewedApr 3, 2026

Neuronal APOE4-induced Early Hippocampal Network Hyperexcitability in Alzheimers Disease Pathogenesis

Dennis R. Tabuena, Sung-Soo Jang, Brian P. Grone…·Misha Y. Zilberter

This study identifies early hippocampal network hyperexcitability in APOE4 mice, linked to Nell2 overexpression, and shows its role in AD pathogenesis.

10 citationstop 1%

mousebulk RNA-seq

𝕏 PostBluesky

NeurosciencebioRxivPreprintDec 9, 2025

Neuronal APOE4 drives damaging lipid accumulation via contact-dependent neuron-oligodendrocyte-microglia interaction in Alzheimer's disease

Min Joo Kim, Jessica R. Blumenfeld, Yaqiao Li…·Yadong Huang

This study shows neuronal APOE4 drives lipid accumulation in AD through neuron-oligodendrocyte-microglia interactions, with microglia showing preferential lipid buildup.

1 citation

mousebulk RNA-seq

𝕏 PostBluesky

BioinformaticsbioRxivPreprintDec 8, 2025

Tri-AD: Hippocampal cell-type-specific responses to age, sex and APOE genotype

Yaqiao Li, Yanxia Hao, Carlota Pereda Serras…·Marina Sirota

The paper investigates how age, sex, and APOE genotype affect hippocampal cell-type-specific gene expression and communication in mice, revealing sex-divergent effects of APOE4.

DOI 10.64898/2025.12.03.691944

mousesnRNA-seq

𝕏 PostBluesky

NeurosciencebioRxivPreprintNov 10, 2023

Microglia Depletion Reduces Human Neuronal APOE4-Driven Pathologies in a Chimeric Alzheimer's Disease Model

Antara T. Rao, Nuo Chen, Min Joo Kim…·Yadong Huang

The paper investigates the role of microglia in APOE4-driven Alzheimer's pathology using a chimeric model, finding that microglia are required for APOE4-induced pathologies.

8 citations

mousehuman

𝕏 PostBluesky