Brian P. Grone

This study identifies early hippocampal network hyperexcitability in APOE4 mice, linked to Nell2 overexpression, and shows its role in AD pathogenesis.

The paper investigates how age, sex, and APOE genotype affect hippocampal cell-type-specific gene expression and communication in mice, revealing sex-divergent effects of APOE4.

This study compares NF-κB activity in two jellyfish species, showing differences in transcriptional activation and subcellular localization.

The paper investigates the role of microglia in APOE4-driven Alzheimer's pathology using a chimeric model, finding that microglia are required for APOE4-induced pathologies.

This study identifies early and persistent effects of APOE4 on neuronal gene expression networks in aging, suggesting the need for early interventions in Alzheimer's disease.

The paper generates zebrafish models for 8 catastrophic childhood epilepsy genes and develops a classification scheme and open-source database for these models.