Author

M. A. Geeves

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Biophysics· 1 Cell Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:statistical model· 3 Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Organism:mouse· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

C. A. Johnson· 3 shared L. A. LEINWAND· 3 shared C. D. Vera· 2 shared D. P. Mulvihill· 2 shared J. Walklate· 2 shared M. Svicevic· 2 shared A. Adhikari· 1 shared A. Combs· 1 shared

Activity by Year

2018-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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3 shared papersBiochemistry

C. A. Johnson

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Danicamtiv increases myosin recruitment and alters the chemomechanical cross bridge cycle in cardiac muscle

K. B. Kooiker, S. Mohran, K. L. Turner, W. Ma, G. Flint, L. Qi, C. Gao, Y. Zheng, T. S. McMillen, C. Mandrycky, A. Martinson, M. Mahoney-Schaefer, J. C. Freeman, E. G. Costales Arenas, A.-Y. Tu, , F. Moussavi-Harami

This study investigates how Danicamtiv increases force and alters cardiac muscle contraction kinetics by modulating myosin function and cross bridge dynamics in cardiac tissue.

bioRxiv · Jan 31, 2023 · PreprintPhysiology

Myosin motor domains carrying mutations implicated in early or late onset Hypertrophic Cardiomyopathy have similar properties

C. D. Vera, C. A. Johnson, J. Walklate, A. Adhikari, M. Svicevic, S. Mijailovich, A. Combs, S. J. Langer, K. M. Ruppel, J. A. Spudich, M. A. Geeves, L. A. LEINWAND

The paper analyzes myosin motor domain mutations in Hypertrophic Cardiomyopathy to compare early and late onset mutations, finding no clear functional differences but identifying distinct changes from DCM mutations.

bioRxiv · Aug 10, 2019Biophysics

Cardiac contraction velocity has evolved to match heart rate with body size through variation in β-cardiac myosin sequence.

C. A. Johnson, J. E. McGreig, C. D. Vera, D. P. Mulvihill, M. Ridout, L. A. LEINWAND, M. N. Wass, M. A. Geeves

The paper identifies amino acid sites in β-cardiac myosin associated with body mass and shows that altering these sites can adjust contraction velocity and ADP release rate.

bioRxiv · Jul 2, 2019 · PreprintBiochemistry

The ATPase cycle of Human Muscle Myosin II Isoforms: Adaptation of a single mechanochemical cycle for different physiological roles.

C. A. Johnson, J. Walklate, M. Svicevic, S. M. Mijailovich, C. Vera, A. Karabina, L. A. Leinwand, M. A. Geeves

The paper uses MUSICO to model how cross-bridge cycles of human myosin II isoforms predict muscle fiber contraction characteristics.

bioRxiv · Jun 14, 2019Biochemistry

TorC2 dependent phosphorylation modulates calcium regulation of fission yeast myosin.

K. B. Baker, I. A. Gyamfi, G. I. Mashanov, J. E. Molloy, M. A. Geeves, D. P. Mulvihill

The paper investigates how TORC2-dependent phosphorylation of myosin-1 in fission yeast affects calcium regulation and cell growth during mitotic and meiotic cycles.

bioRxiv · Dec 18, 2018 · PreprintCell Biology