M. A. Scull

Inhibition of SARS-CoV-2 Infection in Human Airway Epithelium with a Xeno-Nucleic Acid Aptamer

This study shows that FANA-R8-9 aptamer inhibits SARS-CoV-2 infection in human airway epithelium models and is stable and non-toxic.

Mucus physically restricts influenza A viral particle access to the epithelium

This study shows mucus traps influenza A virus through physical barriers, not just sialic acid binding, and synthetic hydrogels with similar structures can block infection.

MUC5B mobilizes and MUC5AC spatially aligns mucociliary transport on human airway epithelium

The paper investigates the roles of MUC5B and MUC5AC in mucociliary clearance using KO models and finds impaired transport when either mucin is absent.

Rhinovirus C replication is associated with the endoplasmic reticulum and triggers cytopathic effects in an in vitro model of human airway epithelium

This study investigates RV-C15 replication in human airway epithelium, identifying the endoplasmic reticulum as the primary replication site and revealing cytopathic effects on epithelial function.

Membrane-Tethered Mucin 1 is Stimulated by Interferon in Multiple Cell Types and Antagonizes Influenza A Virus Infection in Human Airway Epithelium

This study investigates how MUC1 interacts with influenza A virus in human airway epithelium and shows that MUC1 expression increases during infection, potentially limiting viral spread.

Modeling airway dysfunction in asthma using synthetic mucus biomaterials

This paper develops a synthetic mucus biomaterial to model asthma-related airway dysfunction and shows it mimics key properties of native mucus in health and disease.

Influenza A virus diffusion through mucus gel networks

This study quantifies influenza A virus diffusion through human airway mucus, finding that mesh structure, not neuraminidase activity, primarily influences virus mobility.