Gli2 Facilitates Tumor Immune Evasion and Immunotherapeutic Resistance by Coordinating Wnt Ligand and Prostaglandin Signaling
N. C. DeVito, Y.-V. Nguyen, M. Sturdivant, M. P. Plebanek, K. Howell, N. Yarla, V. Jain, M. Aksu, G. Beasley, B. Theivanthiran, B. A. Hanks
This paper identifies Gli2 as a key driver of immune evasion and immunotherapy resistance in tumors through Wnt and prostaglandin signaling, offering a therapeutic target for combination immunotherapies.
bioRxiv · Mar 31, 2024Cancer Biology