K. Deland

Ataxia-telangiectasia mutated (Atm) disruption sensitizes spatially-directed H3.3K27M/TP53 diffuse midline gliomas to radiation therapy

This study shows that disrupting ATM enhances radiation therapy efficacy in p53-mutant DMGs but not p53-wildtype DMGs using mouse models.

Atrx deletion impairs cGAS-STING signaling and increases response to radiation and oncolytic herpesvirus in sarcoma

This study shows that ATRX deletion in sarcomas increases sensitivity to radiation and oncolytic herpesvirus by impairing cGAS-STING signaling and reducing immune response.

56Fe ion exposure increases the incidence of lung and brain tumors at a similar rate in male and female mice

This study shows that 56Fe ion exposure increases lung and brain tumor incidence similarly in male and female mice, with 56Fe ions causing faster tumor development than X-rays.

Atm loss does not radiosensitize a primary mouse model of Pten-deleted brainstem glioma

This study develops a mouse model of PTEN-mutated brainstem glioma and finds that ATM deletion does not enhance radiation efficacy in this model.

Tumor genotype dictates radiosensitization after Atm deletion in brainstem gliomas

This study shows that deleting Atm in p53-deficient brainstem gliomas enhances radiosensitivity, while p53 wild-type tumors respond to radiotherapy regardless of Atm status.