C. E. Stewart

Ataxia-telangiectasia mutated (Atm) disruption sensitizes spatially-directed H3.3K27M/TP53 diffuse midline gliomas to radiation therapy

This study shows that disrupting ATM enhances radiation therapy efficacy in p53-mutant DMGs but not p53-wildtype DMGs using mouse models.

Exercise on cytokine responses in males and females: Effect of leucine, HMB and BCAA.

This study examines how leucine, HMB, and BCAA affect post-exercise cytokine responses in males and females, finding sex-specific differences in cytokine levels and responses to supplementation.

Evidence of Disrupted-in Schizophrenia 1 (DISC1) as an arsenic binding protein and implications regarding its role as a translational activator

This study shows DISC1 binds arsenic via a C-terminal cysteine motif and suggests it acts as a sensor and translational modulator in the Akt/mTOR pathway.

Atm loss does not radiosensitize a primary mouse model of Pten-deleted brainstem glioma

This study develops a mouse model of PTEN-mutated brainstem glioma and finds that ATM deletion does not enhance radiation efficacy in this model.

Replicative ageing perturbs the metabolic signature of murine C2C12 skeletal myotubes

This study examines how replicative ageing affects metabolic profiles in murine C2C12 myotubes, finding reduced mitochondrial efficiency and altered amino acid metabolism.

(--)-Epicatechin alters reactive oxygen and nitrogen species production independent of mitochondrial respiration in human vascular endothelial cells

Degradation of ribosome and chaperone proteins is attenuated during the Differentiation of Replicatively Aged C2C12 Myoblasts

This study shows that replicatively aged C2C12 myoblasts have reduced protein degradation, particularly of ribosomal and chaperone proteins, during differentiation, leading to impaired fusion and proteome quality.

Neuromuscular fatigue and recovery after strenuous exercise depends on skeletal muscle size and stem cell characteristics

This study identifies factors like muscle size and stem cell characteristics that influence neuromuscular fatigue and recovery after repeated maximal sprinting in humans.

Knockdown of the E3 Ubiquitin ligase UBR5 and its role in skeletal muscle anabolism

This study shows that knocking down UBR5 leads to skeletal muscle atrophy by disrupting anabolic signaling pathways.

DNA methylation across the genome in aged human skeletal muscle tissue and stem cells: The role of HOX genes and physical activity

This study identifies age-related hypermethylation in HOX genes in aged human skeletal muscle and stem cells, with physical activity inversely affecting methylation in some genes.