Ataxia-telangiectasia mutated (Atm) disruption sensitizes spatially-directed H3.3K27M/TP53 diffuse midline gliomas to radiation therapy
A. Mangoli, S. Wu, H. Q. Liu, M. Aksu, V. J. Jain, B. E. Foreman, J. A. Regal, L. B. Weidenhammer, C. E. Stewart, M. E. Guerra Garcia, E. Hocke, K. Abramson, N. T. Williams, L. Luo, K. Deland, , Z. J. Reitman
This study shows that disrupting ATM enhances radiation therapy efficacy in p53-mutant DMGs but not p53-wildtype DMGs using mouse models.
bioRxiv · Oct 18, 2023Cancer Biology