TOLLIP resolves lipid-induced EIF2 signaling in alveolar macrophages for durable Mycobacterium tuberculosis protection.
S. Venkatasubramanian, C. Plumlee, K. Dill-McFarland, G. Pearson, S. B. Cohen, A. Lietzke, S. A. Hinderstein, R. Pryor, S. A. Soleimanpour, M. Altman, K. B. Urdahl, J. A. Shah
This study shows TOLLIP prevents lipid-induced EIF2 activation in alveolar macrophages, which allows Mycobacterium tuberculosis replication and reduces protection.
bioRxiv · Aug 24, 2020 · PreprintImmunology