S. B. Cohen

CD4-mediated immunity shapes neutrophil-driven tuberculous pathology

This study shows that prior immunity influences tuberculosis lesion structure by modulating neutrophil and T cell responses, leading to different pathological outcomes.

Re-appraising the role of T-cell derived interferon gamma in restriction of Mycobacterium tuberculosis in the murine lung

This study shows T cell-derived IFN-gamma is critical for controlling Mycobacterium tuberculosis in the murine lung, despite equivalent bacterial burdens in T cell-deficient mice.

Assessing vaccine-mediated protection in an ultra-low dose Mycobacterium tuberculosis murine model

This study evaluates BCG vaccine efficacy using an ultra-low dose Mtb murine model, showing enhanced protection compared to conventional models.

TCAB1 prevents nucleolar accumulation of the telomerase RNA to promote telomerase assembly

This study shows that TCAB1 prevents telomerase RNA from accumulating in the nucleolus, which is necessary for telomerase assembly.

TOLLIP resolves lipid-induced EIF2 signaling in alveolar macrophages for durable Mycobacterium tuberculosis protection.

This study shows TOLLIP prevents lipid-induced EIF2 activation in alveolar macrophages, which allows Mycobacterium tuberculosis replication and reduces protection.

A mechanism for the extension and unfolding of parallel telomeric G-quadruplexes by human telomerase at single-molecule resolution

This study uses single-molecule techniques to show that telomerase can extend and unfold parallel telomeric G-quadruplexes, revealing it acts as a resolvase.

BCG-induced T cells shape Mycobacterium tuberculosis infection before reducing the bacterial burden

This study shows BCG vaccination shifts infected cell types in mice, with T cell activation preceding bacterial burden reduction.