m6A methylation potentiates cytosolic dsDNA recognition in a sequence-specific manner
M. Balzarolo, S. Engels, A. de jong, K. Franke, T. K. van den Berg, E. M. Janssen, B. van Steensel, M. Wolkers
This study shows that m6A methylation on specific DNA sequences enhances immune recognition by macrophages and dendritic cells through STING-dependent pathways, with sequence-specific immunostimulatory or suppressive effects.
bioRxiv · Aug 21, 2019Immunology