Author

M. Wolkers

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 6

Signature Assays, Organisms & Methods

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Organism:human· 5 Approach:experimental assay· 4 Assay:proteomics· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Research Focus:host-pathogen & immune response· 2

Frequent Co-Authors

A. Guislain· 5 shared B. P. Nicolet· 3 shared B. Nicolet· 2 shared A. Bradaric· 1 shared A. de jong· 1 shared A. Jurgens· 1 shared A. Palazon· 1 shared A. Veenhof· 1 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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5 shared papersImmunology

A. Guislain

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Tertiary lymphoid structure-related immune infiltrates in NSCLC tumor lesions correlate with low tumor-reactivity of TIL products

S. M. Castenmiller, N. Kanagasabesan, A. Guislain, B. Nicolet, M. van Loenen, K. Monkhorst, A. Veenhof, E. Smit, K. Hartemink, J. Haanen, R. de Groot, M. Wolkers

This study identifies that high B cell infiltrates in NSCLC tumors, associated with tertiary lymphoid structures, negatively correlate with the tumor-reactivity of expanded TIL products.

bioRxiv · Feb 19, 2024Immunology

Learning the sequence code of protein expression in human immune cells

B. P. Nicolet, A. Jurgens, K. Bresser, A. Guislain, A. Bradaric, M. Wolkers

SONAR, a machine learning pipeline, learns the sequence code for protein abundance in human immune cells, revealing cell type-specific and activation-dependent sequence features that can enhance T cell receptor expression.

bioRxiv · Sep 1, 2023Immunology

The two enantiomers of 2-hydroxyglutarate differentially regulate cytotoxic T cell function

I. P. Foskolou, P. P. Cunha, E. Minogue, B. Nicolet, A. Guislain, C. Jorgensen, N. D. Zandhuis, L. Barbieri, D. Bargiela, D. Nathanael, P. Tyrakis, A. Palazon, M. Wolkers, R. S. Johnson

This study shows S-2HG and R-2HG differentially regulate CD8+ T cell function, with S-2HG enhancing anti-tumour activity and T cell fitness.

bioRxiv · Aug 18, 2022Immunology

m6A methylation potentiates cytosolic dsDNA recognition in a sequence-specific manner

M. Balzarolo, S. Engels, A. de jong, K. Franke, T. K. van den Berg, E. M. Janssen, B. van Steensel, M. Wolkers

This study shows that m6A methylation on specific DNA sequences enhances immune recognition by macrophages and dendritic cells through STING-dependent pathways, with sequence-specific immunostimulatory or suppressive effects.

bioRxiv · Aug 21, 2019Immunology

CD29 marks superior cytotoxic human CD8+ T cells

B. P. Nicolet, A. Guislain, F. P. J. van Alphen, R. Gomez-Eerland, T. N. M. Schumacher, M. van den Biggelaar, M. Wolkers

This study identifies CD29 as a marker for cytotoxic CD8+ T cells, showing its stability and utility in enhancing anti-tumoral activity.

bioRxiv · Aug 9, 2019Immunology

Costimulation through TLR2 drives polyfunctional CD8+ T cell responses

F. Salerno, J. J. Freen-van Heeren, A. Guislain, B. P. Nicolet, M. Wolkers

This study shows TLR2 ligands lower antigen thresholds for cytokine production and enhance polyfunctional CD8+ T cell responses through mRNA stabilization and costimulation.

bioRxiv · Nov 5, 2018Immunology