Author

O. Villafraz

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Assay:metabolomics· 3 Research Focus:cell type annotation· 2 Organism:human· 2 Research Focus:metabolism & bioenergetics· 1

Frequent Co-Authors

F. Bringaud· 4 shared J.-C. Portais· 3 shared M. Biran· 3 shared N. Plazolles· 3 shared E. Cahoreau· 2 shared E. Pineda· 2 shared E. Tetaud· 2 shared H. Baudouin· 2 shared

Activity by Year

2019-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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4 shared papersMicrobiology

F. Bringaud

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4 papers

Recent·Most cited

The trypanosome UDP-glucose pyrophosphorylase is imported by piggybacking into glycosomes where unconventional sugar nucleotide synthesis takes place

O. Villafraz, H. Baudouin, M. Mazet, H. Kulyk, J.-W. Dupuy, E. Pineda, C. Y. Botte, D. Inaoka, J.-C. Portais, F. Bringaud

This study shows that UDP-glucose pyrophosphorylase (UGP) is imported into glycosomes by piggybacking on phosphoenolpyruvate carboxykinase (PEPCK) and that both cytosolic and glycosomal UGP pathways are functional in trypanosomes.

bioRxiv · Feb 17, 2021Microbiology

Fly stage trypanosomes recycle glucose catabolites and TCA cycle intermediates to stimulate growth in near physiological conditions

O. Villafraz, M. Biran, E. Pineda, N. Plazolles, E. Cahoreau, R. Ornitz, T. Magali, S. Allmann, E. Tetaud, L. Riviere, A. Silber, M. P. Barrett, A. Zikova, M. Boshart, J.-C. Portais, F. Bringaud

This study shows procyclic trypanosomes can use TCA cycle intermediates and glucose catabolites for growth in the fly midgut, expanding their metabolic flexibility.

bioRxiv · Dec 17, 2020Microbiology

Metabolic selection of a homologous recombination mediated loss of glycosomal fumarate reductase in Trypanosoma brucei

M. wargnies, N. Plazolles, R. Schenk, O. Villafraz, J.-W. Dupuy, M. Biran, S. Bachmaier, H. Baudouin, C. Clayton, M. Boshart, F. Bringaud

The paper shows that a deletion event between FRDg and FRDm2 genes is selected in PEPCK knockout cells, leading to a non-functional chimeric gene that reduces growth, suggesting FRD's role in ROS production for parasite differentiation.

bioRxiv · Nov 29, 2020Microbiology

\"Metabolic contest\", a new way to control carbon source preference

S. Allmann, M. Wargnies, E. Cahoreau, M. Biran, N. Plazolles, M. Pauline, E. Pineda Ramirez, H. Kulyk, C. Asencio, O. Villafraz, L. Riviere, E. Tetaud, B. Rotureau, A. Mourier, J.-C. Portais, F. Bringaud

The paper introduces a new mechanism called 'metabolic contest' that regulates carbon source preference in trypanosomes without nutrient sensing or signaling.

bioRxiv · Oct 10, 2019 · PreprintMicrobiology