Author

J.-C. Portais

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Biochemistry· 1 Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Assay:metabolomics· 5 Research Focus:cell type annotation· 3 Organism:human· 3 Research Focus:metabolism & bioenergetics· 3 Research Focus:cancer & tumor microenvironment· 2 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

E. Cahoreau· 3 shared F. Bringaud· 3 shared O. Villafraz· 3 shared A. Mourier· 2 shared E. Pineda· 2 shared E. Tetaud· 2 shared H. Kulyk· 2 shared L. Riviere· 2 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

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3 shared papersMicrobiology

E. Cahoreau

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Weak neuronal glycolysis sustains cognition and organismal fitness

D. Jimenez-Blasco, J. Agulla, R. Lapresa, M. Garcia-Macia, V. Bobo-Jimenez, D. Garcia-Rodriguez, I. Manjarres-Raza, E. Fernandez, Y. Jeanson, S. Khoury, J.-C. Portais, D. Padro, P. Ramos-Cabrer, P. Carmeliet, A. Almeida, J. P. Bolanos

This study shows that weak neuronal glycolysis supports cognition and organismal fitness by preventing mitochondrial redox stress and maintaining autophagy.

bioRxiv · Sep 2, 2023Cell Biology

Cytidine deaminase regulates mitochondrial biogenesis in pancreatic cancer cells

A. Frances, A. Lumeau, L. Stuani, M. Gayral, E. Salland, N. Bery, D. Pagan, N. Hanoun, J. Torrisani, A. Lemarie, J.-C. Portais, L. Buscail, N. Dusetti, J.-E. Sarry, P. Cordelier

This study shows that Cytidine deaminase (CDA) promotes mitochondrial biogenesis and oxidative phosphorylation in pancreatic cancer cells, independent of its deaminase activity, revealing new therapeutic targets.

bioRxiv · Dec 15, 2022 · PreprintCancer Biology

MDH2 is a metabolic switch rewiring the fuelling of respiratory chain and TCA cycle

T. Molinie, E. Cougouilles, C. David, E. Cahoreau, J.-C. Portais, A. Mourier

This study identifies MDH2 as a metabolic switch that regulates NADH oxidation in the respiratory chain and TCA cycle by modulating OAA production and complex I/II activity.

bioRxiv · Apr 17, 2021Biochemistry

The trypanosome UDP-glucose pyrophosphorylase is imported by piggybacking into glycosomes where unconventional sugar nucleotide synthesis takes place

O. Villafraz, H. Baudouin, M. Mazet, H. Kulyk, J.-W. Dupuy, E. Pineda, C. Y. Botte, D. Inaoka, J.-C. Portais, F. Bringaud

This study shows that UDP-glucose pyrophosphorylase (UGP) is imported into glycosomes by piggybacking on phosphoenolpyruvate carboxykinase (PEPCK) and that both cytosolic and glycosomal UGP pathways are functional in trypanosomes.

bioRxiv · Feb 17, 2021Microbiology

Fly stage trypanosomes recycle glucose catabolites and TCA cycle intermediates to stimulate growth in near physiological conditions

O. Villafraz, M. Biran, E. Pineda, N. Plazolles, E. Cahoreau, R. Ornitz, T. Magali, S. Allmann, E. Tetaud, L. Riviere, A. Silber, M. P. Barrett, A. Zikova, M. Boshart, J.-C. Portais, F. Bringaud

This study shows procyclic trypanosomes can use TCA cycle intermediates and glucose catabolites for growth in the fly midgut, expanding their metabolic flexibility.

bioRxiv · Dec 17, 2020Microbiology

\"Metabolic contest\", a new way to control carbon source preference

S. Allmann, M. Wargnies, E. Cahoreau, M. Biran, N. Plazolles, M. Pauline, E. Pineda Ramirez, H. Kulyk, C. Asencio, O. Villafraz, L. Riviere, E. Tetaud, B. Rotureau, A. Mourier, J.-C. Portais, F. Bringaud

The paper introduces a new mechanism called 'metabolic contest' that regulates carbon source preference in trypanosomes without nutrient sensing or signaling.

bioRxiv · Oct 10, 2019 · PreprintMicrobiology