Genome-wide CRISPR screens identify essential cell growth mediators in BRAF-inhibitor resistant melanoma
Z. Li, B. Wang, S. Gu, P. Jiang, A. Sahu, C.-H. Chen, T. Han, S. Shi, X. Wang, N. Traugh, H. Liu, Y. Liu, Q. Wu, M. Brown, T. Xiao, , S. Liu
The paper identifies key regulators of BRAF inhibitor resistance in melanoma using CRISPR screens and integrates multi-omics data to reveal CDK6-dependent mechanisms.
bioRxiv · Dec 16, 2019Cancer Biology