Author

X. S. Liu

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cancer Biology· 6 Physiology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 6 Organism:human· 6 Assay:bulk RNA-seq· 4 Research Focus:cell type annotation· 4 Research Focus:differential expression· 4 Organism:mouse· 4 Research Focus:gene regulatory network inference· 3 Approach:statistical model· 3

Frequent Co-Authors

M. Brown· 4 shared H. W. Long· 3 shared K. Lim· 3 shared P. Cejas· 3 shared X. Wang· 3 shared A. Font-Tello· 2 shared C. Tokheim· 2 shared C. Wang· 2 shared

Activity by Year

2020-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

4 shared papersCancer Biology

M. Brown

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

A Genetically Encoded Actuator Selectively Boosts L-type Calcium Channels in Diverse Physiological Settings

P. J. del Rivero Morfin, D. Scala Chavez, S. Jayaraman, L. Yang, A. Kochiss, H. M. Colecraft, X. S. Liu, S. O. Marx, A. M. Rajadhyaksha, M. Ben-Johny

This paper develops GeeC, a genetically encoded actuator that boosts L-type CaV1.2/1.3 channel function in cardiomyocytes and neurons, enhancing calcium influx and excitation-transcription coupling.

bioRxiv · Sep 22, 2023 · PreprintPhysiology

Multiplex Epigenome Editing of MECP2 to Rescue Rett Syndrome Neurons

J. Qian, X. Guan, B. Xie, C. Xu, J. Niu, X. Tang, C. Li, H. Colecraft, R. Jaenisch, X. S. Liu

This study uses multiplex epigenome editing to reactivate MECP2 from the inactive X chromosome in RTT neurons, rescuing neuronal defects in vitro.

bioRxiv · Nov 30, 2022 · PreprintPhysiology

Data-driven discovery of targets for bipotent anticancer drugs identifies Estrogen Related Receptor Alpha

A. Sahu, X. Wang, P. Munson, J. Klomp, X. Wang, S. Gu, G. Qian, P. Nicol, Z. Zeng, C. Wang, C. Tokheim, W. Zhang, J. Fu, J. Wang, N. Nair, , K. Flaherty

BipotentR identifies immune-metabolic regulators for bipotent anticancer drugs, demonstrating ESRRA inhibition's effects on tumor metabolism and immune mechanisms.

bioRxiv · Oct 25, 2021 · PreprintCancer Biology

A molecular switch between mammalian MLL complexes dictates response to Menin-MLL inhibition

Y. M. Soto-Feliciano, F. J. Sanchez-Rivera, F. Perner, D. W. Barrows, E. R. Kastenhuber, Y.-J. Ho, T. Carroll, Y. Xiong, D. Anand, A. Soshnev, L. Gates, M. C. Beytagh, D. Cheon, S. Gu, X. S. Liu, , C. D. Allis

The paper identifies a molecular switch between MLL1-Menin and MLL3/4-UTX complexes that determines response to Menin-MLL inhibitors in leukemia.

bioRxiv · Oct 22, 2021Cancer Biology

FGFR inhibitor mediated dismissal of SWI/SNF complexes from YAP-dependent enhancers induces adaptive therapeutic resistance

Y. Li, X. Qiu, X. Wang, H. Liu, R. Geck, A. K. Tewari, T. Xiao, A. Font-Tello, K. Lim, J. L. Kristen, M. Morrow, R. Vadhi, P.-L. Kao, A. Jaber, S. Yerrum, , M. Brown

The paper shows that FGFR inhibitors cause SWI/SNF complex dismissal from YAP-dependent enhancers, leading to adaptive resistance in TNBC through epigenetic and metabolic changes.

bioRxiv · Mar 2, 2021Cancer Biology

In Vivo CRISPR Screens Identify E3 Ligase Cop1 as a Modulator of Macrophage Infiltration and Cancer Immunotherapy Target

X. Wang, C. Tokheim, B. Wang, S. S. Gu, Q. Tang, Y. Li, N. Traugh, Y. Zhang, Z. W. Li, B. Zhang, J. Fu, T. Xiao, W. Li, C. A. Meyer, J. Chu, , X. S. Liu

The paper identifies Cop1 as a modulator of macrophage infiltration and cancer immunotherapy in TNBC by using in vivo CRISPR screens and multi-omics analyses.

bioRxiv · Dec 9, 2020Cancer Biology

Subtype Heterogeneity and Epigenetic Convergence in Neuroendocrine Prostate Cancer

P. Cejas, Y. Xie, A. Font-Tello, K. Lim, S. Symala, X. Qiu, A. Tewari, N. Shah, H. Nguyen, R. Patel, L. Brown, I. Coleman, W. M. Hackeng, L. Brosens, K. Dreijerink, , H. W. Long

This study identifies two distinct subtypes of neuroendocrine prostate cancer based on neuronal transcription factors and highlights their epigenetic convergence and therapeutic implications.

bioRxiv · Sep 13, 2020Cancer Biology

Bone marrow adipogenic lineage precursors (MALPs) promote osteoclastogenesis in bone remodeling and pathologic bone loss

W. Yu, L. Zhong, L. Yao, Y. Wei, T. Gui, Z. Li, H. Kim, N. Dyment, X. S. Liu, S. Yang, Y. Choi, J. Ahn, L. Qin

This study identifies marrow adipogenic lineage precursors (MALPs) as critical regulators of osteoclastogenesis through RANKL expression, showing their role in both normal bone remodeling and pathologic bone loss.

bioRxiv · Aug 1, 2020Cell Biology

Single-cell analysis reveals diverse stromal subsets associated with immune evasion in triple-negative breast cancer

S. Z. Wu, D. L. Roden, C. Wang, H. Holliday, K. Harvey, A. S. Cazet, K. J. Murphy, B. Pereira, G. Al-Eryani, N. Bartonicek, R. Hou, J. R. Torpy, S. Junankar, C.-L. Chan, E. Lam, , A. Swarbrick

This study identifies diverse stromal subsets in TNBC using single-cell RNA-seq and links them to immune evasion mechanisms and therapeutic targets.

bioRxiv · Jun 4, 2020Cancer Biology