N. Auslander

A selective S-acyltransferase inhibitor suppresses tumor growth

The paper identifies an inhibitor of S-acyltransferase ZDHHC20 that suppresses Kras mutant lung tumor growth and improves survival.

Targeting LxCxE cleft pocket of retinoblastoma protein in M2 macrophages inhibits ovarian cancer progression

This study shows targeting the LxCxE cleft pocket of Rb in M2 macrophages inhibits ovarian cancer progression by reducing immunosuppressive TAMs and enhancing T cell infiltration.

kMermaid: Ultrafast functional classification of microbial reads

kMermaid provides an ultrafast and accurate method for classifying metagenomic reads into functional protein clusters, improving upon existing methods with lower computational demands.

Prediction of the virus incubation period for COVID-19 and future outbreaks

The paper predicts the upper limit of the incubation period for viruses like SARS-CoV-2 using genomic features to aid in outbreak control.

Seeker: Alignment-free identification of bacteriophage genomes by deep learning

Seeker identifies unknown bacteriophages in metagenomic data using deep learning without relying on sequence similarity to known phages.

Genomic determinants of pathogenicity in SARS-CoV-2 and other human coronaviruses

This study identifies genomic features distinguishing highly pathogenic SARS-CoV-2, SARS-CoV, and MERS-CoV from less pathogenic coronaviruses using comparative genomics and machine learning.

Cancer-type specific aneuploidies hard-wire chromosome-wide gene expression patterns of their tissue of origin

The paper shows cancer-type specific aneuploidies correlate with normal tissue gene expression patterns, suggesting they hard-wire chromosome-wide expression levels to support tumorigenesis.