Author

M. C. Lanz

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Assay:proteomics· 5 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Organism:human· 2 Research Focus:protein folding & dynamics· 2 Approach:statistical model· 2 Organism:yeast· 2

Frequent Co-Authors

J. M. Skotheim· 4 shared J. E. Elias· 3 shared G. K. Marinov· 2 shared M. P. Swaffer· 2 shared S. Zhang· 2 shared A. Joiner· 1 shared A. Papagiannakis· 1 shared C. Fromme· 1 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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4 shared papersCell Biology

J. M. Skotheim

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Author profile →

5 papers

Recent·Most cited

Genome concentration limits cell growth and modulates proteome composition in Escherichia coli

J. Makela, A. Papagiannakis, W.-H. Lin, M. C. Lanz, S. Glenn, M. Swaffer, G. K. Marinov, J. M. Skotheim, C. Jacobs-Wagner

The paper shows genome concentration limits transcription and affects proteome composition in E. coli, with effects detectable in nutrient-rich conditions.

bioRxiv · Feb 26, 2024Cell Biology

Genome dilution by cell growth drives starvation-like proteome remodeling in mammalian and yeast cells

M. C. Lanz, S. Zhang, M. P. Swaffer, L. Hernandez Götz, F. McCarty, I. Ziv, D. F. Jarosz, J. E. Elias, J. M. Skotheim

The paper shows that increasing cell size leads to proteome remodeling similar to starvation, driven by genome dilution in mammalian and yeast cells.

bioRxiv · Oct 16, 2023Cell Biology

Cell size contributes to single-cell proteome variation

M. C. Lanz, L. Fuentes Valenzuela, J. E. Elias, J. M. Skotheim

The paper shows that cell size significantly affects protein concentration variation in single-cell proteomics data.

bioRxiv · Oct 17, 2022Cell Biology

Increasing cell size remodels the proteome and promotes senescence

M. C. Lanz, E. Zatulovskiy, M. P. Swaffer, L. Zhang, I. Ilerten, S. Zhang, D. S. You, G. K. Marinov, P. McAlpine, J. E. Elias, J. M. Skotheim

The paper shows that increasing cell size remodels the proteome and promotes senescence, but polyploidization can prevent this by altering the DNA-to-ploidy ratio.

bioRxiv · Jul 29, 2021Cell Biology

In-depth and 3-Dimensional Exploration of the Budding Yeast Phosphoproteome

M. C. Lanz, K. Yugandhar, S. Gupta, E. Sanford, V. Faca, S. Vega, A. Joiner, C. Fromme, H. Yu, M. B. Smolka

The paper presents a comprehensive phosphoproteomic dataset for budding yeast, identifies cell cycle-regulated phosphorylation events, and shows phosphorylation disrupts protein-protein interactions.

bioRxiv · Jul 13, 2019Biochemistry