Fragment-based discovery of a new class of inhibitors targeting mycobacterial tRNA modification
S. E. Thomas, A. J. Whitehouse, K. Brown, J. M. Belardinelli, R. Lahiri, M. D. J. Libardo, P. Gupta, S. Malhotra, H. I. M. Boshoff, M. Jackson, C. Abell, A. G. Coyne, T. L. Blundell, R. A. Floto, V. Mendes
This study identifies new TrmD inhibitors for mycobacterial infections using fragment-based drug discovery, showing activity against multiple mycobacterial species in vitro and in macrophage models.
bioRxiv · May 19, 2019Biochemistry