Author

S. Kohno

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Evolutionary Biology· 2 Biochemistry· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 3 Organism:mouse· 3 Organism:human· 2 Research Focus:metabolism & bioenergetics· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

C. Takahashi· 2 shared M. E. Baker· 2 shared S. Hyodo· 2 shared W. Takagi· 2 shared X. Lin· 2 shared Y. Katsu· 2 shared A. Kenaston· 1 shared A. Sawai· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersCancer Biology

C. Takahashi

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Author profile →

6 papers

Recent·Most cited

Extracellular Histones Promote Calcium Phosphate-Dependent Calcification in Mouse Vascular Smooth Muscle Cells

T. Hoshino, D. Kharaghani, S. Kohno

This study shows extracellular histones promote calcification in mouse vascular smooth muscle cells, likely through dsDNA involvement, and links this to vascular calcification in CKD.

bioRxiv · Aug 31, 2023Cell Biology

NFYA promotes the malignant behavior of triple-negative breast cancer through the regulation of lipid metabolism

N. Okada, C. Ueki, M. Shimazaki, G. Tsujimoto, S. Kohno, H. Muranaka, K. Yoshikawa, C. Takahashi

The paper shows NFYAv1 promotes TNBC malignancy by enhancing lipid metabolism, and targeting this axis could be a therapeutic strategy.

bioRxiv · May 26, 2022 · PreprintCancer Biology

Metabolic flux and flux balance analyses indicate the relevance of metabolic thermogenesis and aerobic glycolysis in cancer cells

N. Okahashi, T. Shima, Y. Kondo, C. Araki, S. Tsuji, A. Sawai, H. Uehara, S. Kohno, H. Shimizu, C. Takahashi, F. Matsuda

The paper uses metabolic flux analysis to show that cancer cells prefer aerobic glycolysis over oxidative phosphorylation due to reduced metabolic heat generation.

bioRxiv · Nov 16, 2021Cancer Biology

N-terminal Domain Regulates Steroid Activation of Elephant Shark Glucocorticoid and Mineralocorticoid Receptors

Y. Katsu, I. M. Shariful, X. Lin, W. Takagi, H. Urushitani, S. Kohno, S. Hyodo, M. E. Baker

The paper shows that the N-terminal domain of elephant shark GR regulates steroid activation, with functional divergence from MR.

bioRxiv · Aug 5, 2020Evolutionary Biology

Identification of a fatty acid-sensitive interaction between mitochondrial uncoupling protein 3 and enoyl-CoA hydratase 1 in skeletal muscle

C. Dao, A. Kenaston, C. L. Riley, K. Hirasaka, S. Kohno, A. Solmonson, S. M. Nowinski, G. Fang, K. Fathe, M. Pfeiffer, X. Yang, T. Nikawa, E. Mills

The paper identifies a fatty acid-sensitive interaction between UCP3 and ECH1 in skeletal muscle mitochondria, enhancing FA oxidation and thermogenesis.

bioRxiv · Nov 1, 2019 · PreprintBiochemistry

Transcriptional Activation of Elephant Shark Mineralocorticoid Receptor by Corticosteroids, Progestins and Spironolactone

Y. Katsu, S. Kohno, K. Oka, X. Lin, S. Otake, N. E. Pillai, W. Takagi, S. Hyodo, B. Venkatesh, M. E. Baker

The paper analyzes the activation of elephant shark mineralocorticoid receptor by corticosteroids and progesterone, finding that aldosterone is absent in cartilaginous fishes and progesterone activates shark MR but not human MR.

bioRxiv · Dec 6, 2018Evolutionary Biology