Author

M. E. Cook

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:mouse· 1 Assay:proteomics· 1 Assay:structural biology· 1

Frequent Co-Authors

A. D. MacKerell· 1 shared A. des Georges· 1 shared A. Grishaev· 1 shared A. Krsitopeit· 1 shared B. M. Roth· 1 shared B. T. Edelson· 1 shared C. Lancaster· 1 shared C. Peralta· 1 shared

Activity by Year

2019-2019 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperBiophysics

A. D. MacKerell

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Author profile →

2 papers

Recent·Most cited

Structure of the cell-binding component of the Clostridium difficile binary toxin reveals a novel macromolecular assembly

X. Xu, R. Ruiz, K. A. Adipietro, C. Peralta, D. Ben-Hail, K. M. Varney, M. E. Cook, B. M. Roth, P. T. Wilder, T. Cleveland, A. Grishaev, H. Neu, S. Michel, W. Yu, D. Beckett, , D. J. Weber

This paper determines the atomic structures of the C. difficile binary toxin CDTb using cryoEM and X-ray crystallography, revealing novel di-heptamer forms and critical domains for toxicity and stability.

bioRxiv · Nov 10, 2019 · PreprintBiophysics

Deficiency in Bhlhe40 impairs resistance to H. polygyrus bakeri and reveals novel Csf2rb-dependent regulation of anti-helminth immunity

N. N. Jarjour, T. R. Bradstreet, E. A. Schwarzkopf, M. E. Cook, C.-W. Lai, S. C.-C. Huang, R. Taneja, T. S. Stappenbeck, S. J. Van Dyken, J. F. Urban, B. T. Edelson

This study shows that Bhlhe40 is essential for TH2 cell immunity against H. polygyrus and reveals redundancy in βC chain-dependent cytokines.

bioRxiv · Jul 18, 2019Immunology