Author

S. J. Van Dyken

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:host-pathogen & immune response· 2 Research Focus:protein folding & dynamics· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:statistical model· 1

Frequent Co-Authors

J. S. Fraser· 2 shared R. E. Diaz· 2 shared R. M. Locksley· 2 shared A. K. Ecker· 1 shared B. A. Barad· 1 shared B. Faust· 1 shared B. T. Edelson· 1 shared C. B. Lopez· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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2 shared papersBiochemistry

J. S. Fraser

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4 papers

Recent·Most cited

Murine Parainfluenza Virus Persists in Lung Innate Immune Cells Sustaining Chronic Lung Pathology

I. A. Castro, Y. Yang, V. Gnazzo, D.-H. Kim, S. J. Van Dyken, C. B. Lopez

This study shows that Sendai virus persists in lung innate immune cells, leading to chronic lung disease by upregulating antiviral and inflammatory genes.

bioRxiv · Nov 7, 2023Microbiology

Structural characterization of ligand binding and pH-specific enzymatic activity of mouse Acidic Mammalian Chitinase

R. E. Diaz, A. K. Ecker, G. J. Correy, P. Asthana, I. D. Young, B. Faust, M. C. Thompson, I. B. Seiple, S. J. Van Dyken, R. M. Locksley, J. S. Fraser

This study characterizes the pH-specific enzymatic activity and ligand binding of mouse AMCase using structural and computational methods, revealing dual activity optima at pH 2 and 7.

bioRxiv · Jun 3, 2023Biochemistry

Differences in the chitinolytic activity of mammalian chitinases on soluble and crystalline substrates

B. A. Barad, L. Liu, R. E. Diaz, R. Basilio, S. J. Van Dyken, R. M. Locksley, J. S. Fraser

This study identifies mutations that enhance chitinase activity on oligomeric substrates but not crystalline chitin, highlighting the importance of using physiologically relevant substrates in enzyme engineering.

bioRxiv · Oct 17, 2019 · PreprintBiochemistry

Deficiency in Bhlhe40 impairs resistance to H. polygyrus bakeri and reveals novel Csf2rb-dependent regulation of anti-helminth immunity

N. N. Jarjour, T. R. Bradstreet, E. A. Schwarzkopf, M. E. Cook, C.-W. Lai, S. C.-C. Huang, R. Taneja, T. S. Stappenbeck, S. J. Van Dyken, J. F. Urban, B. T. Edelson

This study shows that Bhlhe40 is essential for TH2 cell immunity against H. polygyrus and reveals redundancy in βC chain-dependent cytokines.

bioRxiv · Jul 18, 2019Immunology