Author

D. W. Speicher

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

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Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Organism:mouse· 2 Assay:proteomics· 2 Approach:wet-lab / biochemical assay· 2 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

A. Carey· 1 shared A. Kossenkov· 1 shared A. N. Guterres· 1 shared A. R. Goldman· 1 shared A. T. Weeraratna· 1 shared A. V. Kossenkov· 1 shared B. Lipchick· 1 shared D. M. Zundell· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperCancer Biology

A. Carey

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2 papers

Recent·Most cited

Age-related increases in fibroblasts-secreted IGFBP2 increase melanoma cell invasion and lipid synthesis.

G. M. Alicea, M. E. Portuallo, P. Patel, M. E. Fane, A. Carey, D. W. Speicher, A. Kossenkov, V. W. Rebecca, D. Wirtz, A. T. Weeraratna

This study shows that aged fibroblasts secrete more IGFBP2, which promotes melanoma cell invasion and lipid synthesis, and that neutralizing IGFBP2 reduces tumor growth and metastasis.

bioRxiv · May 2, 2023Cancer Biology

Selective abrogation of S6K2 maps lipid homeostasis as a survival vulnerability in MAPKi-resistant NRASmut melanoma

B. Lipchick, A. N. Guterres, H.-Y. Chen, D. M. Zundell, S. Del Aguila, P. I. Reyes-Uribe, S. Basu, X. Yin, A. V. Kossenkov, Y. Lu, G. B. Mills, Q. Liu, A. R. Goldman, M. E. Murphy, D. W. Speicher, J. Villanueva

This study identifies S6K2 as a vulnerability in MAPK inhibitor-resistant NRAS-mutant melanoma, showing its abrogation disrupts lipid homeostasis and triggers cell death.

bioRxiv · Apr 7, 2021 · PreprintCancer Biology