T. Hiraiwa

Generic comparison of lumen nucleation and fusion in epithelial organoids with and without hydrostatic pressure

The paper compares lumen nucleation and fusion dynamics in three epithelial organoid systems under varying hydrostatic pressure conditions, revealing conserved self-organisation rules.

Multiscale mechanisms driving tissue rupture by invading cells

This study identifies a mechanism where invading cells and tissue barriers coordinate to rupture barriers through intercellular adhesions and subcellular contractility, challenging existing models of collective invasion.

Spatio-temporal Coordination of Active Deformation Forces and Wnt / Hippo-Yap Signaling in Hydra Regeneration

The paper investigates how Wnt signaling and tissue deformation coordinate during Hydra regeneration, finding that biomechanical symmetry breaking is regulated by Wnt and stabilized by Hippo-Yap signaling.

Tight junctions regulate lumen morphology via hydrostatic pressure and junctional tension

This study investigates how tight junctions regulate lumen morphology through hydrostatic pressure and junctional tension in MDCKII cysts.

Modelling contractile ring formation and division to daughter cells for simulating proliferative multicellular dynamics

This study introduces a model to simulate subcellular-level cell proliferation dynamics, including contractile ring formation and division, and shows it replicates tissue-scale multicellular behavior.

Curvature-induced cell rearrangements in biological tissues

This study investigates how curvature gradients and anisotropy drive apicobasal T1 transitions in epithelial tissues through competing mechanical mechanisms.

Mechanics defines the spatial pattern of compensatory proliferation

The paper identifies that spatial inhomogeneity in mechanotransduction via YAP drives compensatory proliferation in response to apoptosis.

Polar pattern formation induced by contact following locomotion in a multicellular system

This study identifies contact following locomotion as a mechanism driving polar order in collective cell migration through experiments and simulations in Dictyostelium cells.