M. Girard

Inherited mitochondrial dysfunction triggered by OPA1 mutation impacts the sensory innervation fibre identity, functionality and regenerative potential in the cornea

This study shows that OPA1 mutation causes corneal innervation issues, including reduced sensitivity and impaired regeneration, despite normal epithelial function.

Effect of eye globe and optic nerve morphologies on gaze-induced optic nerve head deformations

This study uses finite element modeling to show that eye morphology and tissue stiffness significantly affect optic nerve head deformations during gaze shifts.

Human-aided dispersal facilitates parasitism escape in the most invasive mosquito species

This study investigates how human-aided dispersal and population bottlenecks affect parasitism in invasive Aedes albopictus mosquitoes, finding that recently introduced populations escape infection.

Heterochromatin flexibility contributes to chromosome segregation in the cell nucleus

This study uses molecular dynamics simulations to show that heterochromatin flexibility influences its distribution in the nucleus, with less flexible heterochromatin segregating toward the interior in the absence of shell interactions.

Finite-size transitions in complex membranes

This paper shows that lipid regulation in membranes can lead to critical behavior and critical composition due to finite-size effects, supporting the critical membrane hypothesis.

Moleculewise semi-grand canonical ensembles

The paper introduces an algorithm to simulate molecules in semi-grand canonical ensembles and enables coupling chemical potentials to collective variables for creating asymmetric membranes.

An Arf/Rab cascade controls the growth and invasiveness of glioblastoma

This study shows that loss of Rab35 or Arf5 in glioblastoma cells increases tumor growth and invasiveness by activating the epidermal growth factor receptor and upregulating SPOCD1.

Regulating lipid composition rationalizes acyl-tail saturation homeostasis in ectotherms

The paper models lipid composition regulation in ectotherms, showing cholesterol increases with temperature to control membrane saturation and viscosity.

RpiRc regulates RsbU to modulate eDNA-dependent biofilm formation and in vivo virulence of Staphylococcus aureus in a mouse model of catheter infection

This study identifies RpiRc as a regulator of eDNA-dependent biofilm formation and virulence in S. aureus, showing reduced biofilm formation and antibiotic tolerance in its mutant.

Chestnut extract but not sodium salicylate decrease the severity of diarrhea and enterotoxigenic Escherichia coli F4 shedding in artificially infected piglets

This study tests chestnut extract and sodium salicylate as alternatives to antibiotics in piglets with post-weaning diarrhea, finding that chestnut extract improves growth and reduces diarrhea severity.

From genotype to antibiotic susceptibility phenotype in Enterobacteriaceae: a clinical perspective

This study evaluates the accuracy of predicting antibiotic susceptibility from whole-genomic sequencing in Enterobacteriaceae, finding high concordance rates but some errors due to chromosomal gene overexpression.

The intestinal microbiota predisposes to traveller’s diarrhoea and to the carriage of multidrug-resistant Enterobacteriaceae after travelling to tropical regions

The study examines how gut microbiota changes during and after travel to tropical regions and its association with traveller’s diarrhoea and multidrug-resistant Enterobacteriaceae (MRE) carriage.

Clinical metagenomics of bone and joint infections: a proof of concept study

This study evaluates clinical metagenomics for identifying pathogens and predicting antibiotic susceptibility in bone and joint infections, showing high accuracy in monomicrobial cases and partial success in polymicrobial cases.