F. Laurent

Exploring the impact of digestive physicochemical parameters of adults and infants on the pathophysiology of Cryptosporidium parvum using the dynamic TIM-1 gastrointestinal model

This study investigates how age-related digestive parameters affect Cryptosporidium parvum infection using an in vitro gastrointestinal model, finding differences in sporozoite release, activity, and invasiveness between adults and infants.

Inositol pyrophosphate catabolism by three families of phosphatases controls plant growth and development

This study identifies three phosphatase families involved in inositol pyrophosphate catabolism in plants, showing their roles in growth, development, and nutrient signaling.

Pervasive sublethal effects of agrochemicals as contributing factors to insect decline

This study shows sublethal agrochemical exposure harms insect behavior, survival, and reproduction, with effects amplified by temperature changes, contributing to insect population decline.

Staphylococcus aureus can use an alternative pathway to be internalized by osteoblasts in absence of β1 integrins

This study shows Staphylococcus aureus can enter osteoblasts without β1 integrins via vβ3/vβ5 integrins, revealing an alternative internalization pathway.

Analysis of in-patient evolution of Escherichia coli reveals potential links to relapse of bone and joint infections

The paper analyzes in-patient evolution of Escherichia coli in bone and joint infections and identifies genetic and phenotypic changes associated with relapse.

YAP promotes cell-autonomous immune responses to tackle intracellular Staphylococcus aureus in vitro

This study shows YAP enhances cell-autonomous immune responses against intracellular Staphylococcus aureus by promoting autophagy and inflammation.

A maximum mean discrepancy approach reveals subtle changes in α-synuclein dynamics

This paper introduces a statistical method to compare biomolecule dynamics across conditions without identifying generating models, showing it detects changes in α-synuclein dynamics during depolarization.

A drug repurposing screen identifies altiratinib as a selective inhibitor of a key regulatory splicing kinase and a potential therapeutic for toxoplasmosis and malaria

This paper identifies altiratinib as a selective inhibitor of PRP4K/CLK3 kinases in apicomplexan parasites, showing broad-spectrum antiparasitic activity against toxoplasmosis and malaria.

Potential role of Mercury pollutants in the success of Methicillin-Resistant Staphylococcus aureus USA300 in Latin America

The paper investigates how mercury pollution may contribute to the dominance of a USA300 variant in South America by enhancing its fitness under mercury exposure.

Metapopulation ecology links antibiotic resistance, consumption and patient transfers in a network of hospital wards

The paper uses metapopulation ecology to analyze how antibiotic use and patient transfers affect antibiotic resistance in hospital wards, finding strong links between antibiotic consumption and resistance variants.

Novel Staphylococcal Cassette Chromosome composite island (SCC-CI) with a new subtype of SCCmecVI cassette found in ST5 MRSA in France

The paper identifies a novel SCC-CI in ST5 MRSA in France, characterized by a mosaic structure including a new SCCmecVI subtype.

Demographic fluctuation of community-acquired antibiotic-resistant Staphylococcus aureus lineages: potential role of flimsy antibiotic exposure

The paper investigates how low-level antibiotic exposure influences the expansion of two CA-MRSA lineages by reversing the fitness cost of antibiotic resistance.

Clinical metagenomics of bone and joint infections: a proof of concept study

This study evaluates clinical metagenomics for identifying pathogens and predicting antibiotic susceptibility in bone and joint infections, showing high accuracy in monomicrobial cases and partial success in polymicrobial cases.