Author

M. Givskov

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:bacteria (other)· 3 Research Focus:cell type annotation· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Assay:proteomics· 2 Organism:C. elegans· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

L. Yang· 2 shared T. Tolker-Nielsen· 2 shared A. Filloux· 1 shared B. G. Fritz· 1 shared B. Ize· 1 shared B. K. Y. Yeo· 1 shared B. Y. Woo· 1 shared C. Chua· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 9 mutual co-author links

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2 shared papersMicrobiology

L. Yang

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Inhibition of Pseudomonas aeruginosa quorum sensing by chemical induction of the MexEF-oprN efflux pump

R. Kristensen, J. B. Andersen, M. Levin Rybtke, C. U. Jansen, B. G. Fritz, R. Kiilerich, J. Uhd, T. Bjarnsholt, K. Qvortrup, T. Tolker-Nielsen, M. Givskov, T. H. Jakobsen

The paper identifies two compounds that inhibit quorum sensing in Pseudomonas aeruginosa by inducing the MexEF-oprN efflux pump, reducing QS-regulated virulence factors.

bioRxiv · Oct 27, 2023 · PreprintMicrobiology

Characterization of TelE, an LXG effector exhibiting a conserved C-terminal glycine zipper motif required for toxicity

W. K. Teh, Y. Ding, F. Gubellini, A. Filloux, C. Poyart, M. Givskov, S. Dramsi

The paper identifies and characterizes TelE, an LXG effector from SGG with pore-forming activity, showing its toxicity and requirement for a conserved glycine zipper motif.

bioRxiv · Sep 7, 2022Microbiology

Disruption of the Pseudomonas aeruginosa Tat system perturbs PQS-dependent quorum sensing and biofilm maturation through loss of the Rieske cytochrome bc1 sub-unit

E. Y.-C. Soh, F. Smith, M. Gimenez, L. Yang, R. Vejborg, M. Fletcher, N. Halliday, S. Bleves, S. Heeb, M. Camara, M. Givskov, K. Hardie, T. Tolker-Nielsen, B. Ize, P. Williams

This study identifies the Pseudomonas aeruginosa Tat pathway's role in PQS-dependent quorum sensing and biofilm maturation by showing that disruption of the Rieske cytochrome bc1 subunit impairs virulence factor production and eDNA release.

bioRxiv · Mar 1, 2021Microbiology

Auranofin inhibits virulence in Pseudomonas aeruginosa

L. Z. W. Tan, J. K. H. Yam, Z. Hong, M. M. S. Salido, B. Y. Woo, S. F. Y. Li, L. Yang, M. Givskov, S.-S. Chng

This study shows that auranofin inhibits virulence in Pseudomonas aeruginosa by targeting Vfr, reducing quorum sensing and Type IV pili, and synergizing with colistin to eliminate biofilms.

bioRxiv · May 13, 2020 · PreprintMicrobiology

Pseudomonas aeruginosa isolates co-incubated with Acanthamoeba castellanii exhibit phenotypes similar to chronic cystic fibrosis isolates

W. Leong, C. Lutz, J. Williams, Y. H. Poh, B. K. Y. Yeo, C. Chua, S. A. Rice, M. Givskov, M. Sanderson-Smith, D. McDougald

This paper shows that Pseudomonas aeruginosa co-incubated with Acanthamoeba castellanii develops genetic and phenotypic traits similar to chronic cystic fibrosis isolates, suggesting similar selection pressures from different host environments.

bioRxiv · Feb 25, 2020 · PreprintMicrobiology