Author

Z. Hong

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 5 Microbiology· 2 Biophysics· 1 Cancer Biology· 1 Evolutionary Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 10 Research Focus:cell signaling & trafficking· 4 Research Focus:cell type annotation· 3 Research Focus:host-pathogen & immune response· 3 Organism:mouse· 3 Assay:proteomics· 3 Research Focus:drug response / drug discovery· 2 Organism:human· 2

Frequent Co-Authors

A. B. Malik· 2 shared J. Adlakha· 2 shared J. Rehman· 2 shared K. Bachmaier· 2 shared K. M. Reinisch· 2 shared P. T. Toth· 2 shared T. Melia· 2 shared Y. Tsukasaki· 2 shared

Activity by Year

2019-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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2 shared papersMicrobiology

A. B. Malik

Mutual co-authors in cluster

Author profile →

11 papers

Recent·Most cited

Spartin-mediated lipid transfer facilitates lipid droplet turnover

N. Wan, Z. Hong, M. A. Parson, J. L. Korfhage, J. E. Burke, T. Melia, K. Reinisch

This study identifies spartin as a lipid transfer protein essential for lipid droplet turnover via lipophagy, revealing a new lipid transport module in its senescence domain.

bioRxiv · Nov 29, 2023Cell Biology

Parallel Activation of Src and Hif1α Increases Localized Glycolytic ATP Generation for Re-assembly of Endothelial Adherens Junctions

L. Wang, P. Gajwani, P. Chaturvedi, Z. Hong, Z. Ye, G. Schwarz, N. Pohl-Avila, A.-M. Ray, S. Krantz, P. T. Toth, D. E. Leckband, A. V. Karginov, J. Rehman

This study shows that Src and Hif1α activation increases glycolytic ATP production near endothelial adherens junctions, facilitating their re-assembly after injury.

bioRxiv · Nov 11, 2022 · PreprintCell Biology

Mechanisms by Which Small Molecule Inhibitors Arrest Sec14 Phosphatidylinositol Transfer Protein Activity

X. R. Chen, L. Poudel, Z. Hong, P. Johnen, S. S. Katti, A. Tripathi, A. H. Nile, S. M. Green, G. Schaaf, F. Bono, v. bankaitis, T. I. Igumenova

This study investigates how small molecule inhibitors affect Sec14 phosphatidylinositol transfer protein activity using structural analysis to inform antifungal drug design.

bioRxiv · Aug 1, 2022 · PreprintBiophysics

Mitoguardin-2 is a lipid transporter and its lipid transfer ability is required for function

Z. Hong, J. Adlakha, E. Guinn, F. Giska, K. Gupta, T. Melia, K. M. Reinisch

This study identifies mitoguardin-2 as a lipid transporter that facilitates lipid transfer between mitochondria and lipid droplets, essential for mitochondrial and lipid droplet function.

bioRxiv · Jul 8, 2022Cell Biology

Structural and biochemical insights into lipid transport by VPS13 proteins.

J. Adlakha, Z. Hong, P. Li, k. M. Reinisch

The paper presents the crystal structure of VPS13s adaptor binding domain complexed with a Pro-X-Pro peptide and shows that scramblases partner with bulk lipid transport proteins.

bioRxiv · Mar 11, 2022Cell Biology

Computer-Vision Stabilized Intravital Imaging Reveals Lung Capillary Neutrophil Dynamics Crucial for Lung Host-Defense Function

Y. Tsukasaki, K. Bachmaier, J. C. Joshi, B. Joshi, P. T. Toth, Z. Hong, S. Nepal, M. Gunzer, J. Cho, D. Mehta, C. Tiruppathi, S. Pinho, J. Rehman, A. B. Malik

This study uses CASTii to analyze lung capillary neutrophil dynamics, revealing their role in host defense and response to infection.

bioRxiv · Apr 19, 2021 · PreprintMicrobiology

Selective Nanotherapeutic Targeting of the Neutrophil Subset Mediating Inflammatory Injury

K. Bachmaier, A. Stuart, Z. Hong, Y. Tsukasaki, A. Singh, S. Chakraborty, A. Mukhopadhyay, X. Gao, M. Maienschein-Cline, P. Kanteti, R. Rehman, A. B. Malik

This study identifies a neutrophil subset responsible for ALI in sepsis and shows that targeting it with nanotherapeutics prevents ALI without harming host defense.

bioRxiv · Jun 30, 2020 · PreprintImmunology

MEKK3-MEK5-ERK5 signaling promotes mitochondrial degradation

J. E. Craig, J. N. Miller, R. R. Rayavarapu, Z. Hong, G. B. Bulut, W. Zhuang, S. M. Sakurada, J. Temirov, J. A. Low, T. Chen, S. M. Pruett-Miller, L. J.-s. Huang, M. B. Potts

This study identifies the MEKK3-MEK5-ERK5 pathway as a positive regulator of basal mitochondrial degradation independent of exogenous stressors.

bioRxiv · May 15, 2020Cell Biology

Auranofin inhibits virulence in Pseudomonas aeruginosa

L. Z. W. Tan, J. K. H. Yam, Z. Hong, M. M. S. Salido, B. Y. Woo, S. F. Y. Li, L. Yang, M. Givskov, S.-S. Chng

This study shows that auranofin inhibits virulence in Pseudomonas aeruginosa by targeting Vfr, reducing quorum sensing and Type IV pili, and synergizing with colistin to eliminate biofilms.

bioRxiv · May 13, 2020 · PreprintMicrobiology

Tumor-infiltrating nerves create an electro-physiologically active microenvironment and contribute to treatment resistance

A. Kovacs, D. W. Vermeer, M. Madeo, H. Reavis, S. J. Vermeer, C. S. Williamson, A. Rickel, J. Stamp, C. T. Lucido, J. Cain, M. Bell, M. Morgan, J.-Y. Yoon, M. A. Mitchell, N. Tulina, , P. D. Vermeer

The paper shows that tumor-infiltrating nerves contribute to treatment resistance and that chemotherapy increases tumor innervation.

bioRxiv · Apr 24, 2020Cancer Biology

Modelling the On-going Natural Selection of Educational Attainment in Contemporary Societies

Z. Hong

The paper uses a simulation model to show that educational attainment may increase short-term but its genetic component may decline, influenced by cultural transmission and selective pressures.

bioRxiv · Apr 17, 2019Evolutionary Biology