Modified HIF expression in CD8+ T cells increases anti-tumor efficacy
P. Velica, P. P. Cunha, N. Vojnovic, I. P. Foskolou, D. Bargiela, M. Gojkovic, H. Rundqvist, R. S. Johnson
This study shows that modifying HIF-2α expression in CD8+ T cells enhances their anti-tumor activity through improved cytotoxic function and resistance to hypoxia.
bioRxiv · Jun 18, 2020 · PreprintImmunology