Author

H. Rundqvist

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:metabolism & bioenergetics· 1

Frequent Co-Authors

I. P. Foskolou· 3 shared P. P. Cunha· 3 shared P. Velica· 3 shared D. Bargiela· 2 shared L. Barbieri· 2 shared M. Gojkovic· 2 shared R. Johnson· 2 shared R. S. Johnson· 2 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersImmunology

I. P. Foskolou

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Author profile →

4 papers

Recent·Most cited

A 2-Hydroxybutyrate-mediated feedback loop regulates muscular fatigue

B. J. Wadsworth, M. Leiwe, E. Minogue, P. P. Cunha, V. Engman, C. Brombach, C. Asvestis, S. K. Sah-Teli, E. Marklund, P. Karppinen, J. L. Ruas, H. Rundqvist, J. Lanner, R. S. Johnson

This study shows that 2-hydroxybutyrate (2HB) produced during exercise inhibits branched-chain aminotransferases, leading to metabolic changes that enhance oxidative capacity.

bioRxiv · Oct 16, 2023Physiology

Lactate regulation of activation in CD8+ T cells

L. Barbieri, P. Velica, P. A. Gameiro, P. P. Cunha, I. P. Foskolou, D. Bargiela, H. Rundqvist, R. Johnson

This study shows lactate can displace glucose as a carbon source for activated CD8+ T cells and alters their transcriptome, affecting effector differentiation markers.

bioRxiv · Dec 14, 2021 · PreprintImmunology

Modified HIF expression in CD8+ T cells increases anti-tumor efficacy

P. Velica, P. P. Cunha, N. Vojnovic, I. P. Foskolou, D. Bargiela, M. Gojkovic, H. Rundqvist, R. S. Johnson

This study shows that modifying HIF-2α expression in CD8+ T cells enhances their anti-tumor activity through improved cytotoxic function and resistance to hypoxia.

bioRxiv · Jun 18, 2020 · PreprintImmunology

Lactate potentiates differentiation and expansion of cytotoxic T cells

H. Rundqvist, P. Velica, L. Barbieri, P. Gameiro, P. Cunha, M. Gojkovic, S. Mijwel, E. Ahlstedt, I. P. Foskolou, M. Ruiz-Perez, M. Arsenian-Henriksson, J. Ule, A. Ostman, R. Johnson

This study shows that lactate enhances the anti-tumour activity of cytotoxic T cells by increasing their proliferation and cytotoxicity during exercise.

bioRxiv · Mar 9, 2019 · PreprintImmunology