Author

P. P. Cunha

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 5 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:human· 6 Research Focus:host-pathogen & immune response· 3 Assay:proteomics· 3 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:metabolism & bioenergetics· 1

Frequent Co-Authors

D. Bargiela· 5 shared I. P. Foskolou· 5 shared L. Barbieri· 4 shared P. Velica· 4 shared R. S. Johnson· 4 shared E. Minogue· 3 shared H. Rundqvist· 3 shared B. J. Wadsworth· 2 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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5 shared papersImmunology

D. Bargiela

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

A 2-Hydroxybutyrate-mediated feedback loop regulates muscular fatigue

B. J. Wadsworth, M. Leiwe, E. Minogue, P. P. Cunha, V. Engman, C. Brombach, C. Asvestis, S. K. Sah-Teli, E. Marklund, P. Karppinen, J. L. Ruas, H. Rundqvist, J. Lanner, R. S. Johnson

This study shows that 2-hydroxybutyrate (2HB) produced during exercise inhibits branched-chain aminotransferases, leading to metabolic changes that enhance oxidative capacity.

bioRxiv · Oct 16, 2023Physiology

Oxygen levels at the time of activation determine T cell persistence and immunotherapeutic efficacy

P. P. Cunha, E. Minogue, L. C. Krause, R. M. Hess, D. Bargiela, B. J. Wadsworth, L. Barbieri, C. Brombach, I. P. Foskolou, I. Bogeski, P. Velica, R. Johnson

The paper shows that low oxygen levels during T cell activation enhance antitumour cytotoxicity, even when subsequent culture is under high oxygen.

bioRxiv · Nov 25, 2022Immunology

Glutarate regulates T cell function and metabolism

E. A. Minogue, P. P. Cunha, A. Quaranta, J. Zurita, S. K. Sah-Teli, B. Wadsworth, R. Hughes, G. Grice, P. Velica, D. Bargiela, L. Barbieri, C. Wheelock, J. A. Nathan, P. Karppinen, I. P. Foskolou, R. S. Johnson

This study shows that glutarate regulates T cell function and metabolism by inhibiting KGDDs and modifying the pyruvate dehydrogenase E2 subunit, enhancing CD8+ T cell cytotoxicity and reducing tumor growth.

bioRxiv · Oct 20, 2022 · PreprintImmunology

The two enantiomers of 2-hydroxyglutarate differentially regulate cytotoxic T cell function

I. P. Foskolou, P. P. Cunha, E. Minogue, B. Nicolet, A. Guislain, C. Jorgensen, N. D. Zandhuis, L. Barbieri, D. Bargiela, D. Nathanael, P. Tyrakis, A. Palazon, M. Wolkers, R. S. Johnson

This study shows S-2HG and R-2HG differentially regulate CD8+ T cell function, with S-2HG enhancing anti-tumour activity and T cell fitness.

bioRxiv · Aug 18, 2022Immunology

Lactate regulation of activation in CD8+ T cells

L. Barbieri, P. Velica, P. A. Gameiro, P. P. Cunha, I. P. Foskolou, D. Bargiela, H. Rundqvist, R. Johnson

This study shows lactate can displace glucose as a carbon source for activated CD8+ T cells and alters their transcriptome, affecting effector differentiation markers.

bioRxiv · Dec 14, 2021 · PreprintImmunology

Modified HIF expression in CD8+ T cells increases anti-tumor efficacy

P. Velica, P. P. Cunha, N. Vojnovic, I. P. Foskolou, D. Bargiela, M. Gojkovic, H. Rundqvist, R. S. Johnson

This study shows that modifying HIF-2α expression in CD8+ T cells enhances their anti-tumor activity through improved cytotoxic function and resistance to hypoxia.

bioRxiv · Jun 18, 2020 · PreprintImmunology