Author

R. S. Johnson

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Cell Biology· 2 Biochemistry· 1 Physiology· 1 Plant Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Assay:proteomics· 7 Organism:human· 6 Research Focus:cell type annotation· 2 Research Focus:host-pathogen & immune response· 2 Assay:metabolomics· 2 Approach:statistical model· 2 Organism:Arabidopsis· 1

Frequent Co-Authors

P. P. Cunha· 4 shared D. Bargiela· 3 shared I. P. Foskolou· 3 shared M. J. MacCoss· 3 shared E. Minogue· 2 shared H. Rundqvist· 2 shared L. Barbieri· 2 shared P. Karppinen· 2 shared

Activity by Year

2017-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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4 shared papersImmunology

P. P. Cunha

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Author profile →

8 papers

Recent·Most cited

A framework for quality control in quantitative proteomics

K. A. Tsantilas, G. E. Merrihew, J. E. Robbins, R. S. Johnson, J. Park, D. L. Plubell, J. D. Canterbury, E. Huang, M. Riffle, V. Sharma, B. X. MacLean, J. Eckels, C. C. Wu, M. S. Bereman, S. E. Spencer, , M. J. MacCoss

The paper introduces a framework for quality control in quantitative proteomics, combining internal and external QC measures with tools for data analysis and deposition.

bioRxiv · Apr 12, 2024Biochemistry

A 2-Hydroxybutyrate-mediated feedback loop regulates muscular fatigue

B. J. Wadsworth, M. Leiwe, E. Minogue, P. P. Cunha, V. Engman, C. Brombach, C. Asvestis, S. K. Sah-Teli, E. Marklund, P. Karppinen, J. L. Ruas, H. Rundqvist, J. Lanner, R. S. Johnson

This study shows that 2-hydroxybutyrate (2HB) produced during exercise inhibits branched-chain aminotransferases, leading to metabolic changes that enhance oxidative capacity.

bioRxiv · Oct 16, 2023Physiology

Glutarate regulates T cell function and metabolism

E. A. Minogue, P. P. Cunha, A. Quaranta, J. Zurita, S. K. Sah-Teli, B. Wadsworth, R. Hughes, G. Grice, P. Velica, D. Bargiela, L. Barbieri, C. Wheelock, J. A. Nathan, P. Karppinen, I. P. Foskolou, R. S. Johnson

This study shows that glutarate regulates T cell function and metabolism by inhibiting KGDDs and modifying the pyruvate dehydrogenase E2 subunit, enhancing CD8+ T cell cytotoxicity and reducing tumor growth.

bioRxiv · Oct 20, 2022 · PreprintImmunology

The two enantiomers of 2-hydroxyglutarate differentially regulate cytotoxic T cell function

I. P. Foskolou, P. P. Cunha, E. Minogue, B. Nicolet, A. Guislain, C. Jorgensen, N. D. Zandhuis, L. Barbieri, D. Bargiela, D. Nathanael, P. Tyrakis, A. Palazon, M. Wolkers, R. S. Johnson

This study shows S-2HG and R-2HG differentially regulate CD8+ T cell function, with S-2HG enhancing anti-tumour activity and T cell fitness.

bioRxiv · Aug 18, 2022Immunology

Stage-specific, morphological and molecular markers of encystation in Giardia lamblia

E. B. Thomas, R. Sutanto, R. S. Johnson, H.-W. Shih, J. Krtkova, M. J. MacCoss, A. R. Paredez

This paper introduces a staging system for Giardia encystation based on ESV morphology and molecular markers, validated through GlRac and Rab GTPase analysis.

bioRxiv · Feb 1, 2021Cell Biology

MICROVASCULAR ENDOTHELIAL CELL ADAPTATION TO HYPOXIA IS ORGAN-SPECIFIC AND CONDITIONED BY ENVIRONMENTAL OXYGEN

M. Reiterer, A. J. Eakin, A. Burke, R. S. Johnson, C. M. Branco

This study shows that microvascular endothelial cells (MVEC) respond to hypoxia differently depending on their organ of origin and environmental oxygen levels, with mitochondrial function playing a key role in their metabolic adaptation.

bioRxiv · Aug 25, 2020Cell Biology

Modified HIF expression in CD8+ T cells increases anti-tumor efficacy

P. Velica, P. P. Cunha, N. Vojnovic, I. P. Foskolou, D. Bargiela, M. Gojkovic, H. Rundqvist, R. S. Johnson

This study shows that modifying HIF-2α expression in CD8+ T cells enhances their anti-tumor activity through improved cytotoxic function and resistance to hypoxia.

bioRxiv · Jun 18, 2020 · PreprintImmunology

Time-resolved Interaction Proteomics of the Putative Scaffold Protein GIGANTEA in Arabidopsis thaliana

J. Krahmer, G. Goralogia, A. Kubota, R. S. Johnson, Y. H. Song, K. Halliday, M. J. MacCoss, T. LeBihan, T. Imaizumi, A. Millar

This study identifies time-specific interactors of the plant protein GIGANTEA using proteomics, revealing a new flowering regulator and non-rhythmic partners involved in proteostasis and metabolism.

bioRxiv · Aug 28, 2017Plant Biology