I. P. Foskolou

Oxygen levels at the time of activation determine T cell persistence and immunotherapeutic efficacy

The paper shows that low oxygen levels during T cell activation enhance antitumour cytotoxicity, even when subsequent culture is under high oxygen.

Glutarate regulates T cell function and metabolism

This study shows that glutarate regulates T cell function and metabolism by inhibiting KGDDs and modifying the pyruvate dehydrogenase E2 subunit, enhancing CD8+ T cell cytotoxicity and reducing tumor growth.

The two enantiomers of 2-hydroxyglutarate differentially regulate cytotoxic T cell function

This study shows S-2HG and R-2HG differentially regulate CD8+ T cell function, with S-2HG enhancing anti-tumour activity and T cell fitness.

Lactate regulation of activation in CD8+ T cells

This study shows lactate can displace glucose as a carbon source for activated CD8+ T cells and alters their transcriptome, affecting effector differentiation markers.

Modified HIF expression in CD8+ T cells increases anti-tumor efficacy

This study shows that modifying HIF-2α expression in CD8+ T cells enhances their anti-tumor activity through improved cytotoxic function and resistance to hypoxia.

Lactate potentiates differentiation and expansion of cytotoxic T cells

This study shows that lactate enhances the anti-tumour activity of cytotoxic T cells by increasing their proliferation and cytotoxicity during exercise.